Biomimetic synthesis and structure elucidation of rubicordifolin, a cytotoxic natural product from Rubia cordifolia.
نویسندگان
چکیده
The biomimetic synthesis and full structural elucidation of rubicordifolin, a cytotoxic natural product isolated from Rubia cordifolia, is described.
منابع مشابه
Antiglycation, Antioxidant and Antidiabetic Activity of Traditional Medicinal Plant: Rubia Cordifolia Linn. for Management of Hyperglycemia
Rubia cordifolia Linn. a flowering plant species from family Rubiaceae is an important medicinal plant. It is known to have anti-diabetic, antiseptic and antistress properties. In the present paper, antiglycation, antioxidant and antidiabetic activities of roots of Rubia cordifolia Linn. were investigated. Anti-AGE (Advance glycation end products) effect of Rubia cordifolia Linn. on glycation o...
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To evaluate the in vivo antioxidant activity of alcoholic extract of the roots of Rubia cordifolia (RC). Male mice, were exposed, either to lead nitrate at a dose containing 40mg/kg body weight or combined with Rubia cordifolia for the first period of 40 days, where the animals were sacrificed for oxidative studies and biochemical studies. Lead has induced a significant increase in LPO, where a...
متن کاملComparative Studies of Rubia Cordifolia Linn. and Rubia Tinctorum Linn (rubiaceae)*
Comparative morphological microscopical and phytochemical studies of root and stem parts of R. cordifolia and R. tinctorum L. (Rubiaceae) have been carried out.
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BACKGROUND Cisplatin is one of the most effective chemotherapeutics against a wide range of cancers including head, neck, ovarian and lung cancers. But its usefulness is limited by its toxicity to normal tissues, including cells of the kidney proximal tubule. The purpose of the present study is to investigate whether the hydro-alcoholic extract of Rubia cordifolia could decrease the intensity o...
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This study was undertaken to investigate the possible effect of hydroalcoholic root extract of Rubia cordifolia against indomethacin-induced enterocolitis in rats. Male Wistar rats received vehicle or hydroalcoholic root extract of Rubia cordifolia (300 and 600 mg/kg) for 11 consecutive days. Enterocolitis was induced by subcutaneous administration of indomethacin (7.5 mg/kg) on 8(th) and 9(th)...
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ورودعنوان ژورنال:
- Journal of the American Chemical Society
دوره 127 9 شماره
صفحات -
تاریخ انتشار 2005